Positions available

Ph.D. Stipends Available – Department of Chemistry, University of Aarhus, Aarhus, Denmark

Controlling and Characterizing the Behavior of Singlet Oxygen in Mammalian Cells

Issues pertinent to the roles played by reactive oxygen species (ROS) in live cells will be studied. Singlet oxygen is a ROS that is important in processes that range from cell death to cell proliferation. It can diffuse over a finite distance in a cell and, as such, is a unique signaling agent. Messages are sent, for example, through its reactions with cellular proteins.
The project focusses on methods to (1) control singlet oxygen production using optogenetic photosensitizers, (2) monitor cell response using microscope-based techniques, and (3) quantify the pertinent photophysical and photochemical processes.
The techniques/tools involved include (1) the use of pulsed femtosecond lasers to perturb cells, (2) the use of super-resolution microscopes to monitor cell response, and (3) the design, characterization, and incorporation of optogenetic proteins in live cells.

Those with interests that range from Physical Chemistry to Molecular Biology are encouraged to contact:
Peter R. Ogilby, Department of Chemistry, University of Aarhus, Aarhus, Denmark
progilby@chem.au.dk
www.chem.au.dk/ppp